In 2001, Morales-Matos established Orfeón San Juan Bautista, a professional choir currently under his co-direction. As an arranger and composer, he has written numerous a cappella choral works. His opus also includes art songs, film scores, choral music with instrumental accompaniment, choral-symphonic works, ballet music, and opera. His compositions and arrangements have been performed in Spain, Italy, Poland, France, Venezuela, Colombia, Mexico, Turkey, Cuba, the Dominican Republic, Canada, the United States of America and Austria.

For nine years, Morales-Matos served as the radio announcer, scriptwriter, and producer for Mayormente a capella, a radio series specialized in choral music aired on Radio Universidad, the University of Puerto Rico’s radio station.

Guarionex Morales-Matos holds a bachelor’s degree in Public Communications and a master’s degree in Cultural Management and Administration, both from the University of Puerto Rico, Río Piedras Campus.